In order to estimate the reliability of wind turbine gearbox based on the system level, a generalized stress-strength model is introduced. Considering that the system works properly under a variety of random stresses which affect every component, the total stress on the system is given by a known linear combination of the stresses of all components. Then the strength of the system can be viewed as a linear combination of the strengths of relative components. In this model, stress and strength are independent of each other. Reliability of the system is the probability that strength exceeds stress. Finally, the reliability of wind turbine gearbox is estimated by the multivariable reliability calculation method. The corresponding result is compared with the results of reliability in the extreme cases (completely dependent and completely independent) by the traditional evaluation method. © 2016, Shanghai Jiaotong University and Springer-Verlag Berlin Heidelberg.