Chronic β-Citronellol Inhalation Rescues Parvalbumin Expression Loss in Prefrontal Cortex of Chronic Restraint Stress Mice

doi:10.1007/s12204-022-2455-0

摘要/Abstract

Abstract: Considerable evidence has revealed that essential oils and their main constituents possess anti- depressant and anxiolytic properties. In the current study, we report the effect of β-citronellol, the main component of rose essential oil, on depressive-like and anxiety-like behaviors in chronic restraint stress (CRS) mice. We found that chronic inhalation of β-citronellol for 14 days could increase locomotor activity in the open field test, de- crease the percentage of immobility duration in the forced swimming test, and increase open arms exploration in elevated plus-maze test in CRS mice. Western blot experiment shows that chronic β-citronellol inhalation res- cues parvalbumin (PV) expression loss in the prefrontal cortex (PFC) of CRS mice. Correlation analysis reveals a strong relationship between the PV expression in PFC and the percentage of sucrose preference of the mice. These findings indicate the relationships between the PV gene expression of PFC and the effects of β-citronellol inhalation.

Key words: chronic reastraint stress (CRS) model, depression, GABAergic neuron, parvalbumin, prefrontal cor- tex (PFC)

中图分类号:

Q189

. [J]. J Shanghai Jiaotong Univ Sci, 2022, 27(4): 512-520.

ZHUANG Qianqian (庄倩倩), ZHUANG Siyue (庄似玥), GONG Yanling (龚艳玲), LI Shengtian∗ (李胜天). Chronic β-Citronellol Inhalation Rescues Parvalbumin Expression Loss in Prefrontal Cortex of Chronic Restraint Stress Mice[J]. J Shanghai Jiaotong Univ Sci, 2022, 27(4): 512-520.

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