Blood Pressure Change in Intrafascicular Vagal Activities

doi:10.1007/s12204-021-2259-7

J Shanghai Jiaotong Univ Sci ›› 2021, Vol. 26 ›› Issue (1): 47-54.doi: 10.1007/s12204-021-2259-7

Blood Pressure Change in Intrafascicular Vagal Activities

GUO Jinyao (郭金尧), LI Runhuan (李润桓), WANG Jiaojiao (王娇娇), ARRANZ Javier, LI Yiran (李怡然), CHAI Xinyu (柴新禹), WANG Jiguang (王继光), SUI Xiaohong (隋晓红)

(1. School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; 2. Shanghai Institute of
Hypertension, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;
3. Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, Jiangsu, China)

出版日期:2021-02-28 发布日期:2021-01-19
通讯作者: WANG Jiguang (王继光), SUI Xiaohong (隋晓红) E-mail: jiguangw@163.com, suixhong@sjtu.edu.cn

Blood Pressure Change in Intrafascicular Vagal Activities

GUO Jinyao (郭金尧), LI Runhuan (李润桓), WANG Jiaojiao (王娇娇), ARRANZ Javier, LI Yiran (李怡然), CHAI Xinyu (柴新禹), WANG Jiguang (王继光), SUI Xiaohong (隋晓红)

(1. School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; 2. Shanghai Institute of
Hypertension, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;
3. Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, Jiangsu, China)

Online:2021-02-28 Published:2021-01-19
Contact: WANG Jiguang (王继光), SUI Xiaohong (隋晓红) E-mail: jiguangw@163.com, suixhong@sjtu.edu.cn

摘要/Abstract

摘要： Baroreflex plays a significant role in modulating blood pressure for the human body. It is known that activation of the vagal nerve related to baroreflex can lead to reductions of blood pressure. However, how the vagal activities quantitatively relate with blood pressure can hardly be achieved. Here fine carbon nanotube yarn (CNTy) electrodes were adopted for recording intrafascicular vagal activities, synchronized with measurement of arterial blood pressure in a rat. Together with a novel algorithm, the results preliminarily quantified that there were six clusters of neural spikes within recorded vagal activities, and the number of individual vagal spikes correspondingly varied with blood pressure. Especially for Cluster 2, the neural activations decreased with arterial blood pressure increasing. This study can shed lights on the quantified neural mechanism underlying the control of vagal activities on blood pressure, and guide the vagal-nerve neuromodulation for treating hypertension.

关键词: vagal nerve, hypertension, baroreflex, signal processing, neuromodulation, carbon nanotube yarn

Abstract: Baroreflex plays a significant role in modulating blood pressure for the human body. It is known that activation of the vagal nerve related to baroreflex can lead to reductions of blood pressure. However, how the vagal activities quantitatively relate with blood pressure can hardly be achieved. Here fine carbon nanotube yarn (CNTy) electrodes were adopted for recording intrafascicular vagal activities, synchronized with measurement of arterial blood pressure in a rat. Together with a novel algorithm, the results preliminarily quantified that there were six clusters of neural spikes within recorded vagal activities, and the number of individual vagal spikes correspondingly varied with blood pressure. Especially for Cluster 2, the neural activations decreased with arterial blood pressure increasing. This study can shed lights on the quantified neural mechanism underlying the control of vagal activities on blood pressure, and guide the vagal-nerve neuromodulation for treating hypertension.

Key words: vagal nerve, hypertension, baroreflex, signal processing, neuromodulation, carbon nanotube yarn

中图分类号:

R 318

GUO Jinyao (郭金尧), LI Runhuan (李润桓), WANG Jiaojiao (王娇娇), ARRANZ Javier, LI Yiran (李怡然), CHAI Xinyu (柴新禹), WANG Jiguang (王继光), SUI Xiaohong (隋晓红) . Blood Pressure Change in Intrafascicular Vagal Activities[J]. J Shanghai Jiaotong Univ Sci, 2021, 26(1): 47-54.

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Blood Pressure Change in Intrafascicular Vagal Activities

Blood Pressure Change in Intrafascicular Vagal Activities

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