上海交通大学学报(英文版) ›› 2014, Vol. 19 ›› Issue (6): 651-662.doi: 10.1007/s12204-014-1562-y

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Sirtuin Functions in the Brain: From Physiological to Pathological Aspects

SHAO Jia-xiang1,2,3 (邵家骧), ZHANG Ting-ting2,3 (张婷婷), LIU Teng-yuan2,3 (刘腾远), QUAN Yi-zhou1,2,3 (全亦周), LI Fan2,3 (李凡), LIU Jie1,2,3 (刘杰),YANG Xiao2,3 (杨霄), XIE Qian2,3 (谢谦), XIA Wei-liang1,2,3* (夏伟梁)   

  1. (1. State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China; 2. School of Biomedical Engineering, Shanghai Jiaotong University, Shanghai 200240, China; 3. Med-X Research Institute, Shanghai Jiaotong University, Shanghai 200030, China)
  • 出版日期:2014-12-31 发布日期:2014-12-08
  • 通讯作者: XIA Wei-liang (夏伟梁) E-mail:wlxia@sjtu.edu.cn

Sirtuin Functions in the Brain: From Physiological to Pathological Aspects

SHAO Jia-xiang1,2,3 (邵家骧), ZHANG Ting-ting2,3 (张婷婷), LIU Teng-yuan2,3 (刘腾远), QUAN Yi-zhou1,2,3 (全亦周), LI Fan2,3 (李凡), LIU Jie1,2,3 (刘杰),YANG Xiao2,3 (杨霄), XIE Qian2,3 (谢谦), XIA Wei-liang1,2,3* (夏伟梁)   

  1. (1. State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China; 2. School of Biomedical Engineering, Shanghai Jiaotong University, Shanghai 200240, China; 3. Med-X Research Institute, Shanghai Jiaotong University, Shanghai 200030, China)
  • Online:2014-12-31 Published:2014-12-08
  • Contact: XIA Wei-liang (夏伟梁) E-mail:wlxia@sjtu.edu.cn

摘要: Sirtuins are a family of nicotinamide adenine dinucleotide (NAD+) dependent deacetylases involved in multiple biological functions including metabolism, inflammation, stress resistance and aging. In mammals, there are seven members (Sirt1—Sirt7), with diversities in their subcellular localizations and enzymatic activities. Here, we review the functions of sirtuins, with a focus on their roles in normal brain physiology such as neural development regulation, body homeostasis maintenance, and memory formation. We also discuss the role of sirtuins in a variety of brain diseases including stroke, Alzheimer’s, Parkinson’s, and motor neuron dysfunction. Because of the emerging functions of sirtuins in brain physiology and pathology, drugs targeting sirtuins may offer potential therapeutic values for brain disorders.

关键词: sirtuin, neural development, hypothalamic function, stroke, neurodegeneration

Abstract: Sirtuins are a family of nicotinamide adenine dinucleotide (NAD+) dependent deacetylases involved in multiple biological functions including metabolism, inflammation, stress resistance and aging. In mammals, there are seven members (Sirt1—Sirt7), with diversities in their subcellular localizations and enzymatic activities. Here, we review the functions of sirtuins, with a focus on their roles in normal brain physiology such as neural development regulation, body homeostasis maintenance, and memory formation. We also discuss the role of sirtuins in a variety of brain diseases including stroke, Alzheimer’s, Parkinson’s, and motor neuron dysfunction. Because of the emerging functions of sirtuins in brain physiology and pathology, drugs targeting sirtuins may offer potential therapeutic values for brain disorders.

Key words: sirtuin, neural development, hypothalamic function, stroke, neurodegeneration

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