上海交通大学学报(英文版) ›› 2014, Vol. 19 ›› Issue (5): 544-549.doi: 10.1007/s12204-014-1538-y

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Unexpected Roles of Long Non-Coding RNAs in Cancer Biology

QI Yinga (戚颖), KANG Ya-nia,b (康亚妮), ZHAO Xiao-donga,b* (赵晓东)   

  1. (a. Key Laboratory of Systems Biomedicine (Ministry of Education); b. School of Biomedical Engineering and Bio-ID Research Center, Shanghai Jiaotong University, Shanghai 200240, China)
  • 出版日期:2014-10-31 发布日期:2014-11-12
  • 通讯作者: ZHAO Xiao-dong (赵晓东) E-mail:xiaodongzhao@sjtu.edu.cn

Unexpected Roles of Long Non-Coding RNAs in Cancer Biology

QI Yinga (戚颖), KANG Ya-nia,b (康亚妮), ZHAO Xiao-donga,b* (赵晓东)   

  1. (a. Key Laboratory of Systems Biomedicine (Ministry of Education); b. School of Biomedical Engineering and Bio-ID Research Center, Shanghai Jiaotong University, Shanghai 200240, China)
  • Online:2014-10-31 Published:2014-11-12
  • Contact: ZHAO Xiao-dong(赵晓东) E-mail:xiaodongzhao@sjtu.edu.cn

摘要: Recent studies show that long non-coding RNAs (lncRNAs) play important roles in the regulation of various biological processes, including chromatin remodeling, dosage-compensation, imprinting, and epigenetic regulation. Aberrant expression of lncRNAs is involved in many complex human diseases, including cancer. In this review, we summarized recent progress on lncRNAs detection methodology with emphasis on their functions and potential implication in cancer diagnosis and therapy.

关键词: long non-coding RNA (lncRNAs), epigenetics, transcription, carcinomas

Abstract: Recent studies show that long non-coding RNAs (lncRNAs) play important roles in the regulation of various biological processes, including chromatin remodeling, dosage-compensation, imprinting, and epigenetic regulation. Aberrant expression of lncRNAs is involved in many complex human diseases, including cancer. In this review, we summarized recent progress on lncRNAs detection methodology with emphasis on their functions and potential implication in cancer diagnosis and therapy.

Key words: long non-coding RNA (lncRNAs), epigenetics, transcription, carcinomas

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