镍催化下乙腈为氰源的芳基三氟甲磺酸酯氰化反应

周堃, 沈增明

Nickel-Catalyzed Cyanation of Aryl Triflates Using Acetonitrile as a Cyano Source

ZHOU Kun, SHEN Zengming

表1 芳基三氟甲磺酸酯氰化反应的条件筛选

Tab.1 Screening of reaction conditions for cyanation of aryl triflates

条目 催化剂 配体 添加剂 产率① /% 1 Ni(OTf)2 dppb - 20 2 Ni(OTf)2 dppe - 11 3 Ni(OTf)2 dppf - 22 4 Ni(OTf)2 dppp - 71(70②) 5 Ni(acac)2 dppp - 53 6 NiCl2 dppp - 62 7 Ni(OTf)2 dppp ZnCl2 70 8 Ni(OTf)2 dppp ZnF2 66 9 Ni(OTf)2 dppp Mg(OTf)2 65 10 Ni(OTf)2 dppp Tf2O 83 11 Ni(OTf)2 dppp Zn(OTf)2 88 12③ Ni(OTf)2 dppp Zn(OTf)2 87 13④ Ni(OTf)2 dppp Zn(OTf)2 0 14③, ⑤ Ni(OTf)2 dppp Zn(OTf)2 89② 15③, ⑥ Ni(OTf)2 dppp Zn(OTf)2 70