To study the stern vibration characteristics of the ship sailing in still water under the action of propeller induced pressure fluctuation, the propeller self-propulsion numerical simulation was conducted based on the Reynolds-averaged Navier-Stokes (RANS) method, in combination with the shear-stress transport (SST) k-ω model. Taking the obtained fluctuating pressure on the hull surface as the external excitation, the acoustic-structure coupling calculation was performed through the structural finite element model coupled with the flow field boundary element model, and a numerical prediction method for the stern vibration of the self-propulsion ship excited by the propeller surface force was established. By analyzing the fluctuating pressure characteristics in the time domain and frequency domain, it is found that the amplitude of the blade frequency component is much larger than that of other frequency components. For the right-handed propeller, the starboard side pressure amplitude above the propeller is higher than that on the port side. The analysis of the corresponding relationship between the propeller fluctuating pressure, the structural inherent characteristics, and the vibration response shows that the coupled mode natural frequency should be far away from the propeller excitation force frequency to reduce the vibration response. The exploration of the effect of modifying stern structure on the vibration response at the same excitation indicates that increasing the plate thickness or installing stiffeners can change the inherent characteristics of the structure, thus avoiding resonance and achieving the vibration reduction effect.