The blood-brain barrier (BBB) protects the brain against exogenous harmful compounds, but it also impedes the delivery of diagnostic and therapeutic agents to the brain, thereby hindering progress of new drug development for central nervous system (CNS) disorders. There are natural substances that can traverse the BBB emerged in organisms. A comprehensive study on their biological interactions with BBB will provide critical insights into the design and development of bioinspired brain-targeted delivery systems. In this paper, a series of brain delivery strategies were discussed with an emphasis on the bioinspired nano-delivery system which has great potential for clinical applications. The research findings could be applied to facilitate the clinical translation of brain-targeted diagnosis and treatment products.
WANG Bin,ZHANG Xueqing
. Challenges and Opportunities in BrainTargeted Delivery[J]. Journal of Shanghai Jiaotong University, 2021
, 55(Sup.1)
: 62
-64
.
DOI: 10.16183/j.cnki.jsjtu.2021.S1.046
［1］O’BROWN N M, PFAU S J, GU C. Bridging barriers: A comparative look at the blood-brain barrier across organisms［J］. Genes & Development, 2018, 32(7/8): 466-478.
［2］ABBOTT N J. Blood-brain barrier structure and function and the challenges for CNS drug delivery［J］. Journal of Inherited Metabolic Disease, 2013, 36(3): 437-449.
［3］PARDRIDGE W M. Blood-brain barrier drug targeting: The future of brain drug development［J］. Molecular Interventions, 2003, 3(2): 90-105.
［4］FAN K, JIA X, ZHOU M, et al. Ferritin nanocarrier traverses the blood brain barrier and kills glioma［J］. ACS Nano, 2018, 12(5): 4105-4115.
［5］FAN K, CAO C, PAN Y, et al. Magnetoferritin nanoparticles for targeting and visualizing tumour tissues［J］. Nature Nanotechnology, 2012, 7(7): 459-464.
［6］LIANG M, FAN K, ZHOU M, et al. H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection［J］. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(41): 14900-14905.
［7］XUE J, ZHAO Z, ZHANG L, et al. Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence［J］. Nature Nanotechnology, 2017, 12(7): 692-700.
［8］DONG X, GAO J, ZHANG C Y, et al. Neutrophil membrane-derived nanovesicles alleviate inflammation to protect mouse brain injury from ischemic stroke［J］. ACS Nano, 2019, 13(2): 1272-1283.
［9］CHAI Z, RAN D, LU L, et al. Ligand-modified cell membrane enables the targeted delivery of drug nanocrystals to glioma［J］. ACS Nano, 2019, 13(5): 5591-5601.
［10］RUAN S, XIE R, QIN L, et al. Aggregable nanoparticles-enabled chemotherapy and autophagy inhibition combined with anti-PD-L1 antibody for improved glioma treatment［J］. Nano Letters, 2019, 19(11): 8318-8332.
