Medical Science

Amyloid Hypothesis or Tau Hypothesis, Which Is Right?

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  • School of Pharmacy; Engineering Research Center of Cell and Therapeutic Antibody of the Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China

Received date: 2021-02-03

  Online published: 2021-04-09

Abstract

This paper introduces amyloidosis, prion, and Aβ/tau proteins in Alzheimer’s disease. It points out that the amyloid hypothesis and the tau hypothesis are two sides of a coin, which reflect the specialty of Alzheimer’s disease among common features of amyloidosis. The elucidations of oligomer structures in Aβ peptide and tau protein have significances in understanding amyloidosis and fighting against Alzheimer’s disease or general amyloidosis.

Cite this article

MA Buyong . Amyloid Hypothesis or Tau Hypothesis, Which Is Right?[J]. Journal of Shanghai Jiaotong University, 2021 , 55(Sup.1) : 58 -59 . DOI: 10.16183/j.cnki.jsjtu.2021.S1.044

References

[1]NGUYEN P H, RAMAMOORTHY A, SAHOO B R, et al. Amyloid oligomers: A joint experimental/computational perspective on Alzheimer’s disease, Parkinson’s disease, type ii diabetes, and amyotrophic lateral sclerosis[J]. Chemical Reviews, 2021, 121(4): 2545-2647. [2]ZHAO J, NUSSINOV R, MA B. Mechanisms of recognition of amyloid-β (Aβ) monomer, oligomer, and fibril by homologous antibodies[J]. Journal of Biological Chemistry, 2017, 292(44): 18325-18343.
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