Recently, zinc and its alloys are proposed as a new generation of biodegradable metal for medical implant. Particularly, porous Zn-based scaffolds with 3D interconnected pore structure were considered as promising candidates for bone tissue engineering scaffold. In order to improve the cytocompatibility of porous Zn scaffold, a bioactive Mg-P coating was firstly prepared on the surface of porous pure Zn scaffold utilizing a chemical conversion method. The morphology, thickness, composition and bonding force of the Mg-P coating were characterized, and the effect of the Mg-P coating on the degradation behavior and biocompatibility of the porous pure Zn scaffold were systematically studied. The results showed that the Mg-P coating consisted of tiny strip-like Mg-P grains which stack with a flower-like orientation. The thickness of the Mg-P coating was about 10 μm and the bonding force was good. The Mg-P coated scaffold presents significantly decreased Zn2+ releasing rate and obviously improved the cytocompatibility, which demonstrates great potential in bone tissue engineering application.
HOU Yi,JIA Gaozhi,HUANG Hua,YUAN Guangyin
. Preparation and Characterization of Bioactive Mg-P Coating on
the Biodegradable Porous Pure Zn Scaffold[J]. Journal of Shanghai Jiaotong University, 2019
, 53(5)
: 521
-528
.
DOI: 10.16183/j.cnki.jsjtu.2019.05.002
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