血-脑屏障能够保护大脑不受外来有害物质影响，但也使药物难以进入大脑，阻碍中枢神经系统疾病的新药研究.生物体内存在能够跨血-脑屏障的天然物质，其生物学机制可以为脑部药物输送系统的设计研发提供指导.本文介绍一系列脑部递送策略，重点介绍具有临床应用潜力的仿生纳米递送系统.研究成果能够促进脑靶向诊疗产品的临床转化.
The blood-brain barrier (BBB) protects the brain against exogenous harmful compounds, but it also impedes the delivery of diagnostic and therapeutic agents to the brain, thereby hindering progress of new drug development for central nervous system (CNS) disorders. There are natural substances that can traverse the BBB emerged in organisms. A comprehensive study on their biological interactions with BBB will provide critical insights into the design and development of bioinspired brain-targeted delivery systems. In this paper, a series of brain delivery strategies were discussed with an emphasis on the bioinspired nano-delivery system which has great potential for clinical applications. The research findings could be applied to facilitate the clinical translation of brain-targeted diagnosis and treatment products.
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