为了揭示黄单胞菌与植物间互作的遗传学基础，培育广谱持久抗病的农作物，本文对这一领域重要研究进展进行了综述.首先指出了黄单胞菌引起植物病害的严重性，分析了黄单胞菌与植物互作如何导致植物抗病或感病，归纳了TALE蛋白主要作用植物的靶标类型，分析了植物基础转录因子TFIIA与NLR类R基因在植物抗病性中的重要性，认为基因编辑TALE蛋白的效应子结合元件(EBE)是未来作物广谱持久抗病育种的重要方向.
To reveal the genetic basis of the interaction between Xanthomonas pathogens and their host plants for breeding durable broad-spectrum resistance crops, the recent important progress in these fields are summarized. The devastation of plant diseases caused by Xanthomonas species is determined by Xanthomonas T3SS effectors, mainly transcription activator-like effectors (TALEs), which target effector-binding element (EBE) sites of either crop resistance (R) or susceptibility (S) genes. Then, the five types of TALE-targets in plants are briefly stated and the importance of plant general transcription factors TFIIA in the activation of NLR-type R genes in plant resistance is stressed. Finally, that gene-editing of EBEs of R or S genes is proposed to be the new strategy for resistance breeding to control crop diseases in the future.
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［2］MA W, ZOU L, ZHIYUAN J I, et al. Xanthomonas oryzae pv. oryzae TALE proteins recruit OsTFIIAγ1 to compensate for the absence of OsTFIIAγ5 in bacterial blight in rice［J］. Molecular Plant Pathology, 2018, 19(10): 2248-2262.
［3］JI Z, JI C, LIU B, et al. Interfering TAL effectors of Xanthomonas oryzae neutralize R-gene-mediated plant disease resistance［J］. Nature Communications, 2016, 7: 13435.
