上海交通大学学报

上海交通大学学报 >

2021 , Vol. 55 >Issue Sup.1: 32 - 33

DOI: https://doi.org/10.16183/j.cnki.jsjtu.2021.S1.033

生命科学

能否人为控制表观遗传的调控？

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  • 上海交通大学 生命科学技术学院， 上海 200240
张雪（1997-），女，河南省新乡市人，博士生，从事比较基因组及遗传性状解析研究.

收稿日期: 2021-02-03

  网络出版日期: 2021-04-09

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Can Regulation of Epigenetics Be Controlled Artificially?

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  • School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

Received date: 2021-02-03

  Online published: 2021-04-09

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摘要

表观遗传学是研究非DNA序列改变所引起的可遗传的表型变化.其科学意义在于补充自然进化的理论，其应用范围已经涉及众多疾病领域.能否通过人为控制表观遗传调控使细胞选择性地遗传性状，从而治疗某些疾病？

关键词： 表观遗传；控制；疾病治疗

本文引用格式

张雪，刘晨光 . 能否人为控制表观遗传的调控？[J]. 上海交通大学学报, 2021 , 55(Sup.1) : 32 -33 . DOI: 10.16183/j.cnki.jsjtu.2021.S1.033

Abstract

Epigenetics is the study of heritable phenotype changes that do not involve alterations in the DNA sequence. It has been used in the evolution theory and disease therapy. Can it be selectively inherited by manipulation? Humans may be able to benefit from new technologies and avoid some harmful epigenetic events.

Key words： epigenetics; regulation; therapy

参考文献

［1］DAWSON M A, KOUZARIDES T. Cancer epigenetics: From mechanism to therapy［J］. Cell, 2012, 150(1): 12-27. ［2］KANWAL R, GUPTA K, GUPTA S. Cancer epigenetics: An introduction［J］. Methods in Molecular Biology, 2015, 1238: 3-25. ［3］LING C, RONN T. Epigenetics in human obesity and type 2 diabetes［J］. Cell Metabolism, 2019, 29(5): 1028-1044. ［4］ZHANG L, LU Q, CHANG C. Epigenetics in health and disease［M］∥Epigenetics in allergy and autoimmunity. Singapore: Springer, 2020: 3-55.
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