衰老问题无法回避,也是困扰科学家们多年的难题.人类衰老的现代主流生物学理论主要分为程序化理论、损伤或误差理论两大类.随着医学水平的不断提高,微循环理论、端粒酶学说等多种新型的衰老学说不断涌现,丰富了该领域的研究视角.但现有理论仍不能较好地解释衰老过程,并就这一问题达成共识,同时许多理论以一种复杂的方式相互关联.理解和检验各种老龄化理论,可以促进人类对衰老机制的理解,并造福于人类.
Aging is an unavoidable problem that has puzzled scientists for years. The programming theory and the damage or error theory are representatives of the modern mainstream biological theories on human aging. With the continuous improvement of medicine, a variety of novel aging theories such as the microcirculation theory and the telomerase theory have emerged, which enrich the research perspectives in this field. But the existing theories are still not good enough to explain the process of aging. Many theories are related to each other in a complex way. The research and test of various aging theories can promote the understanding of the aging mechanism and benefit human beings.
[1]DAVIDOVIC M, SEVO G, SVORCAN P, et al. Old age as a privilege of the “selfish ones”[J]. Aging and Disease, 2010, 1(2): 139-146.
[2]JIN K L. Modern biological theories of aging[J]. Aging and Disease, 2010, 1(2): 72-74.
[3]JIN K L. A microcirculatory theory of aging[J]. Aging and Disease, 2019, 10(3): 676-683.
[4]MCCAY C M. Iodized salt a hundred years ago[J]. Science, 1935, 82(2128): 350-351.
[5]SCHULZ T J, ZARSE K, VOIGT A, et al. Glucose restriction extends caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress[J]. Cell Metabolism, 2007, 6(4): 280-293.
[6]FLORES I, CAYUELA M L, BLASCO M A. Effects of telomerase and telomere length on epidermal stem cell behavior[J]. Science, 2005, 309(5738): 1253-1256.
[7]HAYFLICK L, MOORHEAD P S. The serial cultivation of human diploid cell strains[J]. Experimental Cell Research, 1961, 25(3): 585-621.
[8]CAMPISI J. Cancer, aging and cellular senescence[J]. In Vivo, 2000, 14(1): 183-188.
[9]HERBIG U, FERREIRA M, CONDEL L, et al. Cellular senescence in aging Primates[J]. Science, 2006, 311(5765): 1257.