上海交通大学学报

上海交通大学学报 >

2021 , Vol. 55 >Issue Sup.1: 18 - 19

DOI: https://doi.org/10.16183/j.cnki.jsjtu.2021.S1.026

生命科学

衰老的生物学机制是什么?

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  • 上海交通大学附属第六人民医院 耳鼻咽喉头颈外科，上海 200233
刘峰（1982-），男，江苏省淮安市人，助理研究员，从事睡眠呼吸障碍疾病机制研究.

收稿日期: 2021-02-03

  网络出版日期: 2021-04-09

基金资助

国家自然科学基金项目（81971240），上海市科学技术委员会重点实验室项目（18DZ2260200）

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What Is Biological Mechanism of Aging?

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  • Department of Otolaryngology-Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China

Received date: 2021-02-03

  Online published: 2021-04-09

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摘要

本文介绍衰老研究的科学意义，归纳既往研究中对于衰老背后生物学机制的解释，提出衰老研究中亟需解决的关键问题，指出新兴多组学研究方法是探索衰老机制的一个重要发展方向.

关键词： 衰老；多组学研究；表型组学；遗传因素

本文引用格式

刘峰，殷善开 . 衰老的生物学机制是什么?[J]. 上海交通大学学报, 2021 , 55(Sup.1) : 18 -19 . DOI: 10.16183/j.cnki.jsjtu.2021.S1.026

Abstract

This paper introduces the scientific significance of aging research, and summarizes the biological mechanisms behind aging in previous studies. Besides, it raises several key questions that need to be answered urgently in this area, and indicates that the emerging multiomics research method is an important development direction to explore the biological mechanism.

Key words： aging; multiomics research; phenomics; genetic factors

参考文献

［1］CAMPISI J, KAPAHI P, LITHGOW G J, et al. From discoveries in ageing research to therapeutics for healthy ageing［J］. Nature, 2019, 571(7764): 183-192. ［2］LAUTRUP S, SINCLAIR D A, MATTSON M P, et al. NAD+ in brain aging and neurodegenerative disorders［J］. Cell Metabolism, 2019, 30(4): 630-655. ［3］CHAKRAVARTI D, LABELLA K A, DEPINHO R A. Telomeres: History, health, and hallmarks of aging［J］. Cell, 2021, 184(2): 306-322. ［4］ERMOLAEVA M, NERI F, ORI A, et al. Cellular and epigenetic drivers of stem cell ageing［J］. Nature Reviews Molecular Cell Biology, 2018, 19(9): 594-610. ［5］HOULE D, GOVINDARAJU D R, OMHOLT S. Phenomics: The next challenge［J］. Nature Reviews Genetics, 2010, 11(12): 855-866.
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