上海交通大学学报

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2020 , Vol. 54 >Issue 8: 785 - 791

DOI: https://doi.org/10.16183/j.cnki.jsjtu.2019.068

基于正交试验方法的柔性神经电极优化设计

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  • 上海交通大学 机械系统与振动国家重点实验室, 上海 200240
谢 颉(1995-),女,江西省吉安市人,硕士生,主要从事神经电极优化设计研究

收稿日期: 2019-03-14

  网络出版日期: 2020-08-18

基金资助

国家自然科学基金资助项目(51675330)

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Optimization Design of Flexible Neural Electrodes Based on Orthogonal Experimental Method

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  • State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai 200240, China

Received date: 2019-03-14

  Online published: 2020-08-18

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摘要

对柔性神经电极进行优化设计,综合弹性模量、电极厚度、楔形角这3个参数进行研究,利用正交试验设计的思想设置试验组,采用ANSYS软件研究不同试验组的脑组织最大应变,并根据试验结果提出组合式柔性神经电极的设计思路.研究结果表明,在弹性模量为8.5GPa、电极厚度为15μm、楔形角为45° 的情况下,微动造成的脑组织最大应变最小,为 5.5627×10-2.一种中间层聚合物弹性模量为5.5GPa,两边层聚合物弹性模量为8.5GPa的三明治结构的组合式柔性电极,在微动损伤以及植入形变上均具有一定的优势.

关键词： 柔性电极; 有限元; 正交试验; 优化设计

本文引用格式

谢颉, 张文光, 尹雪乐, 李伟 . 基于正交试验方法的柔性神经电极优化设计[J]. 上海交通大学学报, 2020 , 54(8) : 785 -791 . DOI: 10.16183/j.cnki.jsjtu.2019.068

Abstract

In order to optimize the design of flexible neural electrodes, three parameters of elastic modulus, electrode thickness, and wedge angle are comprehensively studied. The experimental groups are established based on orthogonal experimental design. The maximum strain of brain tissue in different experimental groups are evaluated by ANSYS. In addition, a new hybrid flexible electrode is designed based on the stimulation results. The experimental results reveal that when elastic modulus is 8.5GPa, thickness is 15μm and wedge angle is 45°, the maximum strain of brain tissue due to micromotion is the smallest, i.e., 5.5627×10-2. Moreover, a sandwich-type hybrid flexible neural electrode is designed with an elastic modulus of 8.5GPa on both sides and an elastic modulus of 5.5GPa in the intermediate layer. The sandwich-type structure can effectively reduce micromotion damage and implant deformation compared to the traditional electrode.

Key words： flexible electrode; finite element; orthogonal experiment; optimized design

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