豚鼠耳蜗基底膜的振动特性

上海交通大学学报（自然版） ›› 2016, Vol. 50 ›› Issue (02): 200-203.

豚鼠耳蜗基底膜的振动特性

塔娜1，许立富1，饶柱石1，黄新生2，周雷2

塔娜1，许立富1，饶柱石1，黄新生2，周雷2 (1. 上海交通大学振动、冲击、噪声研究所，机械系统与振动国家重点试验室，上海 200240； 2. 复旦大学附属中山医院耳鼻喉科，上海 200032)

收稿日期:2014-12-19 出版日期:2016-02-29 发布日期:2016-02-29
基金资助:
国家自然科学基金项目（11072145, 81170910）,上海市科学技术委员会项目（114119a6500）资助

Vibration Characteristics of Cochlear Basilar Membrane in Guinea Pig

TA Na1,XU Lifu1,RAO Zhushi1,HUANG Xinsheng2,ZHOU Lei2

(1. Institute of Vibration, Shock and Noise, State Key Laboratory of Mechanical System and Vibration, Shanghai Jiaotong University, Shanghai 200240, China； 2. Department of EarNoseThroat, Zhongshan Hospital, Fudan University, Shanghai 200032, China)

Received:2014-12-19 Online:2016-02-29 Published:2016-02-29

摘要/Abstract

摘要： 摘要：为探讨豚鼠耳蜗基底膜的听觉机制，利用多普勒激光测振技术进行了声音在28只成年健康豚鼠耳中传递的测试实验.将豚鼠麻醉后切断头取出听泡，采用电钻暴露其耳蜗基底膜，利用多普勒激光测振仪在给定的声压级、频率的纯音激励条件下测量豚鼠外耳道耳蜗基底膜的振动速度，并测量了中耳镫骨的振动速度.结果表明，豚鼠外耳道基底膜具有频率选择特性，而且其基底膜的振动具有行波特性.

关键词: 豚鼠, 镫骨, 耳蜗, 多普勒激光, 听觉机制, 振动特性

Abstract: Abstract： In order to study the auditory mechanism of the guniea pig cochlea, the stapes footplate (SF) and basilar membrane (BM) velocity responses to pure tone were measured using a laser Doppler velocimetry which was able to measure subnanometer vibration from the middle ear and cochlea of the guinea pig. The BM velocity was measured by a reflective microbeads placed onto the scala tympani surface of the BM. The velocity response of the SF was also tested, allowing the calculation of a BM transfer function. The transfer function shows typical tuning features. For a given BM location, the characteristic frequency (CF) of the BM was about 11 kHz. The results show that frequency selectivity and travelling wave exist in the BM.

Key words: Key words： guinea pig, stapes, cochlea, Doppler laser, auditory mechanism； vibration characteristics

中图分类号:

塔娜1，许立富1，饶柱石1，黄新生2，周雷2. 豚鼠耳蜗基底膜的振动特性[J]. 上海交通大学学报（自然版）, 2016, 50(02): 200-203.

TA Na1,XU Lifu1,RAO Zhushi1,HUANG Xinsheng2,ZHOU Lei2. Vibration Characteristics of Cochlear Basilar Membrane in Guinea Pig [J]. Journal of Shanghai Jiaotong University, 2016, 50(02): 200-203.

参考文献

［1］BEKESY G V. Experiments in hearing ［M］. New York: McGrawHill Book Company, Inc, 1960. ［2］RHRODE W S. Observations of the vibration of the basilar membrane in squirrel monkeys using the Mssbauer technique ［J］. J Acoust Soc Am, 1971, 49(4): 12181231. ［3］SELLICK P, PATUZZI R, JOHNSTONE B. Measurement of basilar membrane motion in the guinea pig using the Mssbauer technique ［J］. J Acoust Soc Am, 1982, 72(1): 131141. ［4］KHANNA S, LEONARD D. Measurement of basilar membrane vibrations and evaluation of the cochlear condition ［J］. Hearing Research, 1986, 23(1): 3753. ［5］ROBLES L, RUGGERO M A, RICH N C. Basilar membrane mechanics at the base of the chinchilla cochlea. I. Inputoutput functions, tuning curves, and response phases ［J］. J Acoust Soc Am, 1986, 80(5):13641374. ［6］NUTTALL A L, DOLAN D F, AVINASH G. Laser Doppler velocimetry of basilar membrane vibration ［J］. Hearing Research, 1991, 51(2): 203214. ［7］COOPER N P, RHODE W S. Basilar membrane mechanics in the hook region of cat and guineapig cochlea ［J］. Hearing Research, 1992, 63(12): 163190. ［8］REN T Y, HE W X, GILLESPIE P G. Measurement of cochlear power gain in the sensitive gerbil ear ［J］. Nature Communications, 2011, 2(1): 17. ［9］KEMP D T. Stimulated acoustic emissions from within the human auditory system ［J］. J Acoust Soc Am, 1978, 64(5): 13861391. ［10］ROBLES L, RUGGERO M A, RICH N C. Twotone distortion on the basilar membrane of the chinchilla cochlea ［J］. J Neurophysiol, 1997, 77(5): 23852399. ［11］NUTTALL A L. Twotone suppression of inner hair cell and basilar membrane responses in the guinea pig ［J］. J Acoust Soc Am, 1993, 93(1): 390400. ［12］ROBLES L, RUGGERO M A, RICH N C. Twotone distortion in the basilar membrane of the cochlea ［J］. Nature, 1991, 349: 413424. ［13］刘迎曦, 李生, 孙秀珍. 人耳传声数值模型［J］. 力学学报, 2008, 40(1): 107113. LIU Yingxi, LI Sheng, SUN Xiuzhen. Numerical modeling of human ear for sound transmission ［J］. Chinese Journal of Theoretical and Applied Mechanics, 2008, 40(1): 107113. ［14］王学林, 周健军, 凌玲,等. 含主动耳蜗的人耳传声有限元模拟［J］. 振动与冲击, 2012, 31(21): 4145. WANG Xuelin, ZHOU Jianjun, LING Ling, et al. FE simulation of sound transmission in human ear with an active cochlea model ［J］. Journal of Vibration and Shock, 2012, 31(21): 4145. ［15］王振龙, 王学林, 胡于进,等. 基于中耳与耳蜗集成有限元模型的耳声传递模拟［J］. 中国生物医学工程学报, 2011, 30(1): 6066. WANG Zhenlong, WANG Xuelin, HU Yujin, et al. FEM simulation of sound transmission based on integrated model of niddle ear and cochlea ［J］. Chinese Journal of Biomedical Engineering, 2011, 30(1): 6066. ［16］姚文娟, 黄新生, 李武, 等. 人工听骨不同接入方式对耳结构动力响应的影响［J］. 医用生物力学, 2010, 25(3): 175181. YAO Wenjuan, HUANG Xinsheng, LI Wu, et al. Effect of different connecting methods for artificial ossicle on dynamic response of ear ［J］. Journal of Medical Biomechanics, 2010, 25(3): 175181. ［17］REN T Y, NUTTALL A L. Basilar membrane vibration in the basal turn of the sensitive gerbil cochlea ［J］. Hearing Research, 2001, 151(1): 4860. ［18］REN T Y. Longitudinal pattern of basilar membrane vibration in the sensitive cochlea ［J］. Proceedings of the National Academy of Sciences USA, 2002, 99(26): 1710117106.