上海交通大学学报

上海交通大学学报（自然版） ›› 2013, Vol. 47 ›› Issue (10): 1520-1524.

• 数理科学和化学 • 上一篇    下一篇

微通道中细胞平动对其周围化学微环境的影响

季丽娜，胡延东，李沛晔   

  1. (1.上海交通大学 船舶海洋与建筑工程学院,上海 200240)
  • 收稿日期:2013-01-03 出版日期:2013-10-30 发布日期:2013-10-30
  • 基金资助:

    国家自然科学基金（51206108），国家教育部博士点基金（20120073120016）资助项目

Influence of Cell Movement on Its Chemical Environment in Microchannels

JI Lina,HU Yandong,LI Peiye
  

  1.  (1. School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiaotong University, Shanghai 200240, China)
  • Received:2013-01-03 Online:2013-10-30 Published:2013-10-30

摘要：

主要通过数值模拟研究运动细胞在直通道中对周围浓度梯度场的影响,及对流传质Peclet数、细胞运动速度、细胞运动方向以及细胞大小对细胞周围浓度场的影响.研究发现,细胞在匀速运动一定距离后其周围的最大浓度差的大小和方向与相同位置静止情形下的值的偏差是一个常数，且此常数与传质Peclet数、细胞运动速度及方向、细胞直径等相关.该结论对细胞趋化效应的进一步量化研究具有重要意义.
 

 

关键词: 微通道, 细胞趋化, 细胞增活, 数值模拟, 浓度梯度

Abstract:

The microfluidic technology can produce temporal and spatial stable concentration gradient, which benefits quantitative investigation of living cell chemotaxis. To date, the study of chemotactic effect normally neglected the cell volume and the impact of cell motion. In this paper, the impact of a moving sphere cell on the concentration field was investigated by changing the Peclet number, the velocity of cell and the direction of movements. Results show that the deviation of the maximum concentration difference around a moving cell and a stationary cell at the same spot is close to a constant after a certain time. The maximum concentration difference around a moving cell can be replaced by that of a stationary cell with corrections. This conclusion is valuable to further quantitative chemotactic research.
 

Key words: microchannel, cell chemotaxis, cell chemokinetics, numerical simulation, concentration gradient

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