数字微流控生物芯片的并行在线测试

上海交通大学学报（自然版） ›› 2013, Vol. 47 ›› Issue (01): 98-102.

• 自动化技术、计算机技术 • 上一篇下一篇

数字微流控生物芯片的并行在线测试

张玲1,2，邝继顺2，林静3，梅军进1

(1．湖北理工学院计算机学院，湖北黄石 435003； 2.湖南大学计算机与通信学院, 长沙 410082;3.湖北理工学院医学院, 湖北黄石 435003)

收稿日期:2012-06-15 出版日期:2013-01-30 发布日期:2013-01-30
基金资助:
国家自然科学基金项目(60773207, 60673085)

Parallel On-line Testing for Digital Microfluidic Biochip

ZHANG Ling-1, 2 , KUANG Ji-Shun-2, LIN Jing-3, MEI Jun-Jin-1

(1. School of Computer, Hubei Polytechnic University, Huangshi 435003, Hubei, China;2. School of Computer and Communication, Hunan University, Changsha 410082, China;3. School of Medicine, Hubei Polytechnic Univeristy, Huangshi 435003, Hubei, China)

Received:2012-06-15 Online:2013-01-30 Published:2013-01-30

摘要/Abstract

摘要： 在数字微流控生物芯片的并行测试过程中，将芯片阵列分成等大的子阵列块，在生物实验模块布局的限制下,对相应的子阵列块进行合并与调度,以实现芯片阵列的并行测试.同时，通过实验验证了并行在线测试方法的有效性.结果表明，在不干扰生物实验过程的基础上，所采用的测试方法能够减少测试液滴的数目，提高在线测试的效率.

关键词: 数字微流控生物芯片, 测试调度, 在线测试

Abstract: A new parallel on-line testing scheme for digital microfluidic biochips was proposed. The biochip array under test is divided into same-size sub-arrays first, and these sub-arrays are tested parallel under biochip module placement constraints in the bioassay process. The proposed scheme reduces the number of test droplets and test application time efficiently, and it would not disturb the bioassay process. The experimental results also prove the efficiency of the proposed on-line test scheme.

Key words: digital microfluidic biochip, test schedule, on-line testing

中图分类号:

TP 302

张玲1, 2, 邝继顺2, 林静3, 梅军进1. 数字微流控生物芯片的并行在线测试[J]. 上海交通大学学报（自然版）, 2013, 47(01): 98-102.

ZHANG Ling-1, 2 , KUANG Ji-Shun-2, LIN Jing-3, MEI Jun-Jin-1. Parallel On-line Testing for Digital Microfluidic Biochip[J]. Journal of Shanghai Jiaotong University, 2013, 47(01): 98-102.

参考文献

［1］Su F, Ozev S, Chakrabarty K. Testing of dropletbased microelectrofluidic systems ［C］ ∥ Proceedings of the IEEE International Test Conference. Charlotte, USA: IEEE Computer Society, 2003: 11921200.
［2］Su F, Ozev S, Chakrabarty K. Test planning and test resource optimization for dropletbased microfluidic systems ［C］∥ Proceedings of the IEEE European Test Symposium. France: IEEE Computer Society, 2004: 7277.
［3］Su F, Hwang W, Mukherjee A, et al. Defectoriented testing and diagnosis of digital microfluidicsbased biochips ［C］∥ Proceedings of the IEEE International Test Conference. Autin, USA: IEEE Computer Society, 2005: 486496.
［4］Mitra D, Ghoshal S, Rahaman H, et al. Testing of digital microfluidic biochips using improved eulerization techniques and the Chinese postman problem ［C］∥ 19th IEEE Asian Test Symposium (ATS). Austin, USA: IEEE Computer Society, 2010:111116.
［5］HHHDebasis M, Sarmishtha G,HHH Hafizur R, et al. Test planning in digital microfluidic biochips using efficient eulerization techniques ［J］. Journal of Electronic Testing, 2011, 27(5): 657671.

［6］Su F, Ozev S, Chakrabarty K. Concurrent testing of dropletbased microfluidic systems for multiplexed biomedical assays ［C］ ∥ Proceedings of the IEEE International Test Conference. Charlotte, USA: IEEE Computer Society, 2004: 883892.
［7］Su F, Ozev S, Chakrabarty K. Concurrent testing of digital microfluidicsbased biochips ［J］. ACM Transactions on Design Automation of Electronic System (TODAYS), 2006, 11(2): 442464.
［8］Xu T, Chakrabarty K. Parallel scanlike test and multipledefect diagnosis for digital microfluidic biochips ［J］. IEEE Transaction on Biomedical Circuits and Systems, 2007: 1(2): 148158.
［9］Majumder M, Ray S, Roy S. A multi droplets detection technique for singlefault in digital microfluidic biochip ［C］∥ CIIT 2011. Pune, India: Springer Berlin Heidelberg, 2011: 506511.
［10］Zhao Y, Chakrabarty K, Sturmer R, et al. Optimization techniques for the synchronization of concurrent fluidic operations in pinconstrained digital microfluidic biochips ［J］. IEEE Transactions on Very Large Scale Integration Systems, 2012, 20(6): 11321145.
［11］Roy S, Mitra D, Bhattacharya B B, et al. Pinconstrained designs of digital microfluidic biochips for highthroughout bioassays ［C］∥ International Symposium on Electronic System Design. Bhubaneswar, India: IEEE, 2010: 49.
［12］Zhao Y, Chkrabarty K. Online testing of labonchip using reconfigurable digitalmicrofluidic compactors ［J］. International Journal of Parallel Programming, 2009, 37(4): 370388.
［13］Srinivasan V, Pamula V K, Pollack M G, et al. Clinical diagnositics on human whole blood, plasma, serum, urine, saliva, sweat, and tears on a digital microfluidic platform ［C］∥ 7th International Conference on Miniaturized Chemical and Biochemical Analysis Systems. USA: TRF, 2003: 12871290.

数字微流控生物芯片的并行在线测试

Parallel On-line Testing for Digital Microfluidic Biochip

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